|Application ||WB, FC, E|
|Other Accession||O12948, P04000, P22329, O35476, P0DN77, P0DN78|
|Predicted||Rat, Chicken, Xenopus|
|Calculated MW||40584 Da|
|Antigen Region||21-50 aa|
|Other Names||Medium-wave-sensitive opsin 1, Green cone photoreceptor pigment, Green-sensitive opsin, GOP, OPN1MW, GCP|
|Target/Specificity||This OPN1MW antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human OPN1MW.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OPN1MW Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||The three color pigments are found in the cone photoreceptor cells.|
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Provided below are standard protocols that you may find useful for product applications.
OPN1MW encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness.
Thirumuruganandham, S.P., et al. J Mol Model 15(8):959-969(2009)
Ala-Laurila, P., et al. J. Biol. Chem. 284(24):16492-16500(2009)
Holmes, M.V., et al. PLoS ONE 4 (12), E7960 (2009)
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