PLA2G4B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | P0C869 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 87978 Da |
Antigen Region | 396-424 aa |
Gene ID | 100137049;8681 |
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Other Names | Cytosolic phospholipase A2 beta, cPLA2-beta, Phospholipase A2 group IVB, PLA2G4B |
Target/Specificity | This PLA2G4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the Central region of human PLA2G4B. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PLA2G4B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLA2G4B |
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Function | Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. |
Cellular Location | [Isoform 3]: Cytoplasm, cytosol. Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion. |
Tissue Location | Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
PLA2G4B transcribes naturally-occurring mRNAs that are co-transcribed products of the neighboring JMJD7 and PLA2G4B genes. Incompletely processed read-through transcripts from these two loci are abundantly expressed in most tissues, but the function of the predicted protein product has not yet been determined.
References
Ghosh, M., et al. J. Biol. Chem. 281(24):16615-16624(2006)
Tao, R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 137B (1), 56-58 (2005)
Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005)
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