|Application ||WB, FC, E|
|Calculated MW||87978 Da|
|Antigen Region||396-424 aa|
|Other Names||Cytosolic phospholipase A2 beta, cPLA2-beta, Phospholipase A2 group IVB, PLA2G4B|
|Target/Specificity||This PLA2G4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the Central region of human PLA2G4B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLA2G4B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
PLA2G4B transcribes naturally-occurring mRNAs that are co-transcribed products of the neighboring JMJD7 and PLA2G4B genes. Incompletely processed read-through transcripts from these two loci are abundantly expressed in most tissues, but the function of the predicted protein product has not yet been determined.
Ghosh, M., et al. J. Biol. Chem. 281(24):16615-16624(2006)
Tao, R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 137B (1), 56-58 (2005)
Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005)
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