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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > FUT6 Antibody (Center)
FUT6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P51993 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41860 Da |
| Antigen Region | 102-130 aa |
| Gene ID | 2528 |
|---|---|
| Other Names | Alpha-(1, 3)-fucosyltransferase 6, Fucosyltransferase 6, Fucosyltransferase VI, Fuc-TVI, FucT-VI, Galactoside 3-L-fucosyltransferase, FUT6, FCT3A |
| Target/Specificity | This FUT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the Central region of human FUT6. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FUT6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUT6 (HGNC:4017) |
|---|---|
| Synonyms | FCT3A |
| Function | [Isoform 1]: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants (PubMed:9451035, PubMed:1520296, PubMed:1339443, PubMed:7650030, PubMed:17604274, PubMed:9363434, PubMed:10728707, PubMed:29593094). Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants (PubMed:17604274, PubMed:1339443). Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X (PubMed:10728707). Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates (PubMed:1339443, PubMed:17604274, PubMed:9363434). |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Golgi apparatus. Secreted Note=Membrane-bound form in trans cisternae of Golgi |
| Tissue Location | Kidney, liver, colon, small intestine, bladder, uterus and salivary gland |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
FUT6 is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand.
References
Norden, R., et al. Glycobiology 19(7):776-788(2009)
Higai, K., et al. Glycoconj. J. 25(3):225-235(2008)
Martinez-Duncker, I., et al. Glycobiology 14(1):13-25(2004)
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$ 365.00
$ 140.00
Cat# AP4925c
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