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RPL13A Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP4932b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP4932b-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
RPL13A Antibody (C-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | P40429 |
| Other Accession | Q4R8Z2 |
| Reactivity | Human |
| Predicted | Monkey |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 23577 Da |
RPL13A Antibody (C-term) - Additional info | |
| Gene ID 23521 | |
| Other Names RPL13A; 60S ribosomal protein L13a; 23 kDa highly basic protein | |
| Target/Specificity This RPL13A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 170-200 from the C-terminal region of human RPL13A. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RPL13A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RPL13A Antibody (C-term) - Protein Information | |
| Name RPL13A | |
| Function Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA | |
| Cellular Location Cytoplasm (Probable). | |
RPL13A Antibody (C-term) - Related products
AP4932b: RPL13A Antibody (C-term)
RPL13A Antibody (C-term) - Application data
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Western blot analysis of RPL13A Antibody (C-term) (Cat. #AP4932b) in K562 cell line lysates (35ug/lane). RPL13A (arrow) was detected using the purified Pab.
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RPL13A Antibody (C-term) (Cat. #AP4932b) IHC analysis in formalin fixed and paraffin embedded skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RPL13A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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RPL13A Antibody (C-term) (Cat. #AP4932b) flow cytometric analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
RPL13A Antibody (C-term) - Research Areas
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BACKGROUND
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13P family of ribosomal proteins. It is located in the cytoplasm.
REFERENCES
Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008) Chaudhuri, S., et al. RNA 13(12):2224-2237(2007) Andersen, J.S., et al. Nature 433(7021):77-83(2005)
