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KCNG3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KCNG3 Antibody  (N-term) AP4954a
    Western blot analysis of KCNG3 Antibody (N-term) (Cat. #AP4954a) in mouse liver tissue lysates (35ug/lane). KCNG3 (arrow) was detected using the purified Pab.
  • IHC-P - KCNG3 Antibody  (N-term) AP4954a
    KCNG3 Antibody (N-term) (Cat. #AP4954a) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNG3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8TAE7
Other Accession Q8R523, P59053
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49593 Da
Antigen Region 6-34 aa
Additional Information
Gene ID 170850
Other Names Potassium voltage-gated channel subfamily G member 3, Voltage-gated potassium channel subunit Kv101, Voltage-gated potassium channel subunit Kv63, KCNG3
Target/Specificity This KCNG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human KCNG3.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNG3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNG3
Function Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).
Cellular Location Cell membrane; Multi- pass membrane protein. Cytoplasm. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Remains intracellular in the absence of KCNB1 (PubMed:12060745)
Tissue Location Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745).
Research Areas
Citations (0)

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Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule.

References

Mederos Y Schnitzler, M., et al. J. Biol. Chem. 284(7):4695-4704(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Vega-Saenz de Miera, E.C. Brain Res. Mol. Brain Res. 123 (1-2), 91-103 (2004)

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$ 295.00
$ 99.00
Cat# AP4954a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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