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PAN3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PAN3 Antibody  (C-term) AP4958b
    Western blot analysis of PAN3 Antibody (C-term) (Cat. #AP4958b) in Jurkat cell line lysates (35ug/lane). PAN3 (arrow) was detected using the purified Pab.
  • IHC-P - PAN3 Antibody  (C-term) AP4958b
    PAN3 Antibody (C-term) (Cat. #AP4958b) IHC analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PAN3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - PAN3 Antibody  (C-term) AP4958b
    PAN3 Antibody (C-term) (Cat. #AP4958b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q58A45
Other Accession Q640Q5
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 95613 Da
Antigen Region 771-799 aa
Additional Information
Gene ID 255967
Other Names PAB-dependent poly(A)-specific ribonuclease subunit PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}, PAB1P-dependent poly(A)-nuclease {ECO:0000255|HAMAP-Rule:MF_03181}, PAN deadenylation complex subunit 3 {ECO:0000255|HAMAP-Rule:MF_03181}, hPan3, PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}
Target/Specificity This PAN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 771-799 amino acids from the C-terminal region of human PAN3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}
Function Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins.
Cellular Location Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}
Citations (0)

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PAN3 is functions in cytoplasmic mRNA decay. It is as part of the Pan nuclease complex, recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity.


Uchida, N., et al. J. Biol. Chem. 279(2):1383-1391(2004)

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$ 295.00
$ 99.00
Cat# AP4958b
(40 western blots)
Availability: In Stock
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