|Application ||WB, FC, E|
|Calculated MW||179339 Da|
|Antigen Region||1266-1295 aa|
|Other Names||Transmembrane protein 131-like, KIAA0922, TMEM131L|
|Target/Specificity||This T131L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1266-1295 amino acids from the C-terminal region of human T131L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||T131L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. Isoform 5: Cytoplasm. Note=Scattered throughout the cytoplasm in small-sized punctate structures|
|Tissue Location||Expressed in thymocytes.|
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