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K0406 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP4976a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP4976a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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K0406 Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | O43156 |
| Other Accession | NP_055472 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 122069 Da |
K0406 Antibody (N-term) - Additional info | |
| Gene ID 9675 | |
| Other Names TTI1; KIAA0406; SMG10; TELO2-interacting protein 1 homolog; Protein SMG10 | |
| Target/Specificity This K0406 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 50-80 from the N-terminal region of human K0406. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions K0406 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
K0406 Antibody (N-term) - Protein Information | |
| Name TTI1 | |
| Synonyms KIAA0406, SMG10 | |
| Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals | |
| Cellular Location Cytoplasm. | |
| Tissue Location Widely expressed. | |
K0406 Antibody (N-term) - Related products
K0406 Antibody (N-term) - Application data
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Western blot analysis of K0406 Antibody (N-term) (Cat. #AP4976a) in K562 cell line lysates (35ug/lane). K0406 (arrow) was detected using the purified Pab.
K0406 Antibody (N-term) - Research Areas
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REFERENCES
Olsen, J.V., et al. Cell 127(3):635-648(2006) Deloukas, P., et al. Nature 414(6866):865-871(2001)
