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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   K0406 Antibody (N-term)   

K0406 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - K0406 Antibody  (N-term) AP4976a
    Western blot analysis of K0406 Antibody (N-term) (Cat. #AP4976a) in K562 cell line lysates (35ug/lane). K0406 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43156
Other Accession NP_055472
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 122069 Da
Antigen Region 41-69 aa
Additional Information
Gene ID 9675
Other Names TELO2-interacting protein 1 homolog, Protein SMG10, TTI1, KIAA0406, SMG10
Target/Specificity This K0406 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human K0406.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsK0406 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTI1
Synonyms KIAA0406, SMG10
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Cellular Location Cytoplasm.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Olsen, J.V., et al. Cell 127(3):635-648(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 295.00
$ 99.00
Cat# AP4976a
(40 western blots)
Availability: In Stock
Bulk Size
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