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ASM3A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q92484 |
| Other Accession | Q3ZC91, NP_006705 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51260 Da |
| Antigen Region | 321-349 aa |
| Gene ID | 10924 |
|---|---|
| Other Names | Acid sphingomyelinase-like phosphodiesterase 3a, ASM-like phosphodiesterase 3a, 314-, SMPDL3A, ASML3A |
| Target/Specificity | This ASM3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-349 amino acids from the C-terminal region of human ASM3A. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASM3A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMPDL3A {ECO:0000303|PubMed:25288789, ECO:0000312|HGNC:HGNC:17389} |
|---|---|
| Function | Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling (PubMed:37890481). Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA (PubMed:37890481). Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:28104755, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088). |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood serum. Detected in macrophages (at protein level). |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Wright, K.O., et al. J. Urol. 168(6):2645-2649(2002)
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$ 365.00
$ 140.00
Cat# AP4977b
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