|Application ||WB, IHC-P, FC, E|
|Calculated MW||54366 Da|
|Antigen Region||18-46 aa|
|Other Names||Mitochondrial-processing peptidase subunit beta, Beta-MPP, P-52, PMPCB, MPPB|
|Target/Specificity||This PMPCB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human PMPCB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PMPCB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves presequences (transit peptides) from mitochondrial protein precursors.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
PMPCB is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.
Luczynski, W., et al. Neoplasma 56(5):428-434(2009)
Schwer, B., et al. J. Cell Biol. 158(4):647-657(2002)
Nagao, Y., et al. J. Biol. Chem. 275(44):34552-34556(2000)
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