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SH-PTP2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SH-PTP2 Antibody AP50017
    Western blot analysis of lysates from 293,Hela cell line (from left to right),using SH-PTP2 Antibody(C0321). C0321 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • WB - SH-PTP2 Antibody AP50017
    Western blot analysis of extracts from JK cells (Lane 2), using SH-PTP2 Antibody. The lane on the left is treated with systhesized peptide.
  • IHC - SH-PTP2 Antibody AP50017
    Immunohistochemical analysis of paraffin-embedded human brain tissue using SH-PTP2 antibody .
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q06124
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 68 KDa
Antigen Region 333-366 aa
Additional Information
Gene ID 5781
Other Names Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2
Dilution WB~~ 1:500-1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name PTPN11
Synonyms PTP2C, SHPTP2
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Research Areas
Citations (0)

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Background

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

References

Adachi M.,et al.FEBS Lett. 314:335-339(1992).
Freeman R.M. Jr.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:11239-11243(1992).
Bastien L.,et al.Biochem. Biophys. Res. Commun. 196:124-133(1993).
Ahmad S.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:2197-2201(1993).
Vogel W.,et al.Science 259:1611-1614(1993).

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$ 295.00
Cat# AP50017
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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