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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGS10 Antibody   

RGS10 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RGS10 Antibody AP50030
    Western blot analysis of lysates from K562 cell line ,using RGS10 Antibody(C18309). C18309 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O43665
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 20.21 KDa
Antigen Region 80-113 aa
Additional Information
Gene ID 6001
Other Names Regulator of G-protein signaling 10, RGS10, RGS10
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name RGS10
Function Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).
Cellular Location Cytoplasm, cytosol. Nucleus. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus
Research Areas
Citations (0)

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Background

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.

References

Hunt T.W.,et al.Nature 383:175-177(1996).
Chatterjee T.K.,et al.J. Biol. Chem. 275:24013-24021(2000).
Burgon P.G.,et al.J. Biol. Chem. 276:32828-32834(2001).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 295.00
Cat# AP50030
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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