|Application ||WB, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||41 KDa|
|Antigen Region||50-79 aa|
|Other Names||Proteinase-activated receptor 4, PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3, F2RL3, PAR4|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Kahn M.L.,et al.J. Biol. Chem. 273:23290-23296(1998).
Kahn M.L.,et al.Nature 394:690-694(1998).
Xu W.-F.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:6642-6646(1998).
King M.M.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Kahn M.L.,et al.J. Clin. Invest. 103:879-887(1999).
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