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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   HEXIM1 Antibody   

HEXIM1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HEXIM1 Antibody AP50038
    Western blot analysis of lysates from Hela,HepG2 cell line (from left to right),using HEXIM1 Antibody(C10210). C10210 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • IF - HEXIM1 Antibody AP50038
    Immunofluorescence analysis of HeLa cells, using HES7 antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession O94992
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 41,60(actual) KDa
Antigen Region 201-229 aa
Additional Information
Gene ID 10614
Other Names Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1
Dilution WB~~ 1:1000
IF~~1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name HEXIM1
Synonyms CLP1, EDG1, HIS1, MAQ1
Function Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Cellular Location Nucleus Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050)
Tissue Location Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed Expressed in endocrine tissues.
Research Areas
Citations (0)

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Background

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

References

Kusuhara M.,et al.Biomed. Res. 20:273-279(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wittmann B.M.,et al.Cancer Res. 63:5151-5158(2003).
Ouchida R.,et al.Genes Cells 8:95-107(2003).
Yik J.H.N.,et al.Mol. Cell 12:971-982(2003).

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$ 295.00
Cat# AP50038
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
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