|Application ||WB, IHC|
|Calculated MW||151 KDa|
|Antigen Region||955-983 aa|
|Other Names||Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).
Hacker B.M.,et al.Genomics 50:97-104(1998).
Small K.M.,et al.Pharmacogenetics 13:535-541(2003).
Tantisira K.G.,et al.Hum. Mol. Genet. 14:1671-1677(2005).
Paterson J.M.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Toyota T.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
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