|Calculated MW||H=16;M=18,16;R=17,16; KDa|
|Antigen Region||51-155/155 human aa|
|Other Names||DNA-binding protein inhibitor ID-1, Class B basic helix-loop-helix protein 24, bHLHb24, Inhibitor of DNA binding 1, Inhibitor of differentiation 1, ID1, BHLHB24, ID|
|Format||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce|
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃.|
|Function||Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
Deed R.W.,et al.Biochim. Biophys. Acta 1219:160-162(1994).
Hara E.,et al.J. Biol. Chem. 269:2139-2145(1994).
Zhu W.,et al.Brain Res. Mol. Brain Res. 30:312-326(1995).
Nehlin J.O.,et al.Biochem. Biophys. Res. Commun. 231:628-634(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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