|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||57, KDa|
|Antigen Region||493-522 aa|
|Other Names||Thioredoxin reductase 2, mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin reductase TR3, TXNRD2, KIAA1652, TRXR2|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.|
|Tissue Location||Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling.
Sun Q.-A.,et al.J. Biol. Chem. 274:24522-24530(1999).
Gasdaska P.Y.,et al.FEBS Lett. 442:105-111(1999).
Miranda-Vizuete A.,et al.Eur. J. Biochem. 261:405-412(1999).
Toji S.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Lescure A.,et al.J. Biol. Chem. 274:38147-38154(1999).
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