|Reactivity||Human, Mouse, Rat|
|Calculated MW||90 KDa|
|Antigen Region||189-221 aa|
|Other Names||U4/U6U5 tri-snRNP-associated protein 1, SNU66 homolog, hSnu66, Squamous cell carcinoma antigen recognized by T-cells 1, SART-1, hSART-1, U4/U6U5 tri-snRNP-associated 110 kDa protein, Hom s 1, SART1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.|
|Cellular Location||Nucleus. Note=Found in the nucleus of mitogen- activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells|
|Tissue Location||Ubiquitously expressed.|
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Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
Shichijo S.,et al.J. Exp. Med. 187:277-288(1998).
Makarova O.V.,et al.EMBO J. 20:2553-2563(2001).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
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