|Reactivity||Human, Mouse, Rat|
|Calculated MW||38 KDa|
|Antigen Region||2-32 aa|
|Other Names||Forkhead box protein E1, Forkhead box protein E2, Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5, HFKL5, Thyroid transcription factor 2, TTF-2, FOXE1, FKHL15, FOXE2, TITF2, TTF2|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Synonyms||FKHL15, FOXE2, TITF2, TTF2|
|Function||Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.|
|Tissue Location||Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas|
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Probable transcription factor. Could be involved in thyroid gland organogenesis.
Wiese S.,et al.DNA Cell Biol. 16:165-171(1997).
Chadwick B.P.,et al.Genomics 41:390-396(1997).
Macchia P.E.,et al.Biochimie 81:433-440(1999).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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