CD80 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, E |
---|---|
Primary Accession | P33681 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33048 Da |
Antigen Region | 260-288 aa |
Gene ID | 941 |
---|---|
Other Names | T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B71, B7, CD80, CD80, CD28LG, CD28LG1, LAB7 |
Target/Specificity | This CD80 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the C-terminal region of human CD80. |
Dilution | WB~~1:500-1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CD80 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD80 |
---|---|
Synonyms | CD28LG, CD28LG1, LAB7 |
Function | Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Expressed on activated B-cells, macrophages and dendritic cells |
- Primary Antibodies
- Immunology
- Microbiology
- Signal Transduction
- Antibody Collections
- Catalog Updated
- Host cell receptor for virus entry
- Viral entry into host cell
- Host-virus interaction
- Toll-Like receptor signaling
- Immune system process
- T cell activation
- Allograft rejection
- Intestinal immune network for IgA production
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Provided below are standard protocols that you may find useful for product applications.
Background
CD80 is activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.
References
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
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