|Application ||WB, FC, E|
|Calculated MW||33048 Da|
|Antigen Region||260-288 aa|
|Other Names||T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B71, B7, CD80, CD80, CD28LG, CD28LG1, LAB7|
|Target/Specificity||This CD80 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the C-terminal region of human CD80.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD80 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD28LG, CD28LG1, LAB7|
|Function||Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on activated B-cells, macrophages and dendritic cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CD80 is activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
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