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AKAP1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q92667 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 97,63,149(actual) KDa |
| Antigen Region | 305-333 aa |
| Gene ID | 8165 |
|---|---|
| Other Names | A-kinase anchor protein 1, mitochondrial, A-kinase anchor protein 149 kDa, AKAP 149, Dual specificity A-kinase-anchoring protein 1, D-AKAP-1, Protein kinase A-anchoring protein 1, PRKA1, Spermatid A-kinase anchor protein 84, S-AKAP84, AKAP1, AKAP149, PRKA1 |
| Dilution | IF~~1:100 WB~~ 1:1000 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | AKAP1 (HGNC:367) |
|---|---|
| Synonyms | AKAP149, PRKA1 |
| Function | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). |
| Cellular Location | Mitochondrion outer membrane {ECO:0000250|UniProtKB:O08715}. Mitochondrion {ECO:0000250|UniProtKB:O08715} |
| Tissue Location | Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
References
Trendelenburg G.,et al.Biochem. Biophys. Res. Commun. 225:313-319(1996).
Lin R.-Y.,et al.J. Biol. Chem. 270:27804-27811(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hillman R.T.,et al.Genome Biol. 5:R8.1-R8.16(2004).
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