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GALP Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP5033b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP5033b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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GALP Antibody (C-term) - Product info | |
| Application | WB, FC
|
| Primary Accession | Q9UBC7 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 12545 Da |
GALP Antibody (C-term) - Additional info | |
| Gene ID 85569 | |
| Other Names GALP; Galanin-like peptide | |
| Target/Specificity This GALP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-105 amino acids from the C-terminal region of human GALP. | |
| Dilution WB~~1:100~500WB~~1:1000 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions GALP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
GALP Antibody (C-term) - Protein Information | |
| Name GALP | |
| Function Hypothalamic neuropeptide which binds to the G-protein- coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin- releasing hormone secretion. Isoform 2 exhibits potent and dose- dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2 (By similarity) | |
| Cellular Location Secreted. | |
| Tissue Location Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells | |
GALP Antibody (C-term) - Related products
GALP Antibody (C-term) - Application data
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Western blot analysis of GALP Antibody (C-term) (Cat. #AP5033b) in CEM cell line lysates (35ug/lane).GALP (arrow) was detected using the purified Pab.
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GALP Antibody (C-term) (Cat. #AP5033b) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
GALP Antibody (C-term) - Research Areas
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BACKGROUND
GALP encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction.
REFERENCES
Schjeide, B.M., et al. Neurogenetics 10(1):19-25(2009) Lang, R., et al. Pharmacol. Ther. 115(2):177-207(2007) Santic, R., et al. Proc. Natl. Acad. Sci. U.S.A. 104(24):10217-10222(2007)
