|Application ||WB, FC, E|
|Calculated MW||16628 Da|
|Antigen Region||129-157 aa|
|Other Names||Glutaredoxin-related protein 5, mitochondrial, Monothiol glutaredoxin-5, GLRX5, C14orf87|
|Target/Specificity||This GLRX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-157 amino acids from the C-terminal region of human GLRX5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GLRX5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).|
|Cellular Location||Mitochondrion matrix|
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Provided below are standard protocols that you may find useful for product applications.
GLRX5 is monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. GLRX5 required for normal iron homeostasis. GLRX5 is required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
Bergmann, A.K., et al. Pediatr Blood Cancer 54(2):273-278(2010)
Camaschella, C., et al. Blood 110(4):1353-1358(2007)
Wingert, R.A., et al. Nature 436(7053):1035-1039(2005)
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