KRTAP1-1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
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Primary Accession | Q07627 |
Other Accession | Q9BYS1, Q8IUG1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 18235 Da |
Antigen Region | 1-1 aa |
Gene ID | 81851 |
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Other Names | Keratin-associated protein 1-1, High sulfur keratin-associated protein 11, Keratin-associated protein 11, Keratin-associated protein 16, Keratin-associated protein 17, KRTAP1-1, B2A, KAP11, KAP16, KAP17, KRTAP11 |
Target/Specificity | This KRTAP1-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human KRTAP1-1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KRTAP1-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KRTAP1-1 |
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Synonyms | B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1 |
Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. |
Tissue Location | Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone |
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Provided below are standard protocols that you may find useful for product applications.
Background
KRTAP1-1 is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21.
References
Shimomura, Y., et al. J. Invest. Dermatol. 118(2):226-231(2002)
Rogers, M.A., et al. J. Biol. Chem. 276(22):19440-19451(2001)
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