|Application ||WB, FC, E|
|Other Accession||Q9CQY5, Q5ZJ06|
|Calculated MW||38037 Da|
|Antigen Region||44-71 aa|
|Other Names||Magnesium transporter protein 1, MagT1, Implantation-associated protein, IAP, MAGT1, IAG2|
|Target/Specificity||This MAGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-71 amino acids from the N-terminal region of human MAGT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAGT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Expressed at very low levels in brain, lung and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
MAGT1 encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29.
Zhou, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15750-15755(2009)
Molinari, F., et al. Am. J. Hum. Genet. 82(5):1150-1157(2008)
Shibatani, T., et al. Biochemistry 44(16):5982-5992(2005)
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