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MAGT1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MAGT1 Antibody (N-term) AP5056A
    Western blot analysis of MAGT1 Antibody (N-term) (Cat. #AP5056a) in mouse NIH-3T3 cell line lysates (35ug/lane).MAGT1 (arrow) was detected using the purified Pab.
    detail
  • FC - MAGT1 Antibody (N-term) AP5056A
    MAGT1 Antibody (N-term) (Cat. #AP5056a) flow cytometric analysis of U251 cells (bottom histogram) compared to a negative control (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession Q9H0U3
Other Accession Q9CQY5, Q5ZJ06
Reactivity Human, Mouse
Predicted Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 38037 Da
Antigen Region 44-71 aa
Additional Information
Gene ID 84061
Other Names Magnesium transporter protein 1, MagT1, Implantation-associated protein, IAP, MAGT1, IAG2
Target/Specificity This MAGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-71 amino acids from the N-terminal region of human MAGT1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAGT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGT1 (HGNC:28880)
Synonyms IAG2
Function Accessory component of the STT3B-containing form of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (PubMed:31831667). Involved in N- glycosylation of STT3B-dependent substrates (PubMed:31831667). Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase- independent functions in the STT3B-containing OST complex possibly involving substrate recognition.
Cellular Location Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Ubiquitous. Expressed at very low levels in brain, lung and kidney.
Citations (0)
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Background

MAGT1 encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29.

References

Zhou, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15750-15755(2009)
Molinari, F., et al. Am. J. Hum. Genet. 82(5):1150-1157(2008)
Shibatani, T., et al. Biochemistry 44(16):5982-5992(2005)

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$ 365.00
$ 140.00
Cat# AP5056A
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