|Application ||WB, IF, IHC|
|Calculated MW||27， 37 KDa|
|Antigen Region||62-90 aa|
|Other Names||Tumor necrosis factor ligand superfamily member 12, APO3 ligand, TNF-related weak inducer of apoptosis, TWEAK, Tumor necrosis factor ligand superfamily member 12, membrane form, Tumor necrosis factor ligand superfamily member 12, secreted form, TNFSF12, APO3L, DR3LG|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein|
|Tissue Location||Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain|
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Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Chicheportiche Y.,et al.J. Biol. Chem. 272:32401-32410(1997).
Marsters S.A.,et al.Curr. Biol. 8:525-528(1998).
Pradet-Balade B.,et al.EMBO J. 21:5711-5720(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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