|Reactivity||Human, Mouse, Rat|
|Calculated MW||123, 121, 118, 120, 31 KDa|
|Antigen Region||912-940 aa|
|Other Names||Nuclear export mediator factor NEMF, Antigen NY-CO-1, Serologically defined colon cancer antigen 1, NEMF, SDCCAG1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).|
|Tissue Location||Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role in nuclear export.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Heilig R.,et al.Nature 421:601-607(2003).
Scanlan M.J.,et al.Int. J. Cancer 76:652-658(1998).
Bi X.,et al.Oncogene 24:8229-8239(2005).
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