|Calculated MW||54 KDa|
|Antigen Region||209-238 aa|
|Other Names||Fibroblast growth factor receptor substrate 3, FGFR substrate 3, FGFR-signaling adaptor SNT2, Suc1-associated neurotrophic factor target 2, SNT-2, FRS3|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.|
|Cellular Location||Membrane; Lipid-anchor.|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Xu H.,et al.J. Biol. Chem. 273:17987-17990(1998).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Huang L.,et al.Biochem. Biophys. Res. Commun. 324:1011-1017(2004).
Gotoh N.,et al.FEBS Lett. 564:14-18(2004).
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