|Application ||WB, E|
|Calculated MW||42824 Da|
|Antigen Region||275-303 aa|
|Other Names||Migration and invasion-inhibitory protein, IGFBP2-binding protein, Invasion-inhibitory protein 45, IIp45, MIIP, IIP45|
|Target/Specificity||This MIIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the C-terminal region of human MIIP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MIIP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.|
|Tissue Location||Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells|
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Provided below are standard protocols that you may find useful for product applications.
MIIP inhibits glioma cells invasion and down-regulates adhesion-and motility-associated genes such as NFKB2 and ICAM1. MIIP exhibits opposing effects to IGFBP2 on cell invasion.
Wu, Y., et al. J. Biol. Chem. 285(6):3554-3560(2010) Song, F., et al. Cancer Res. 70(3):1024-1032(2010) Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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