|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||79,83,79,71,67 KDa|
|Antigen Region||600-629 aa|
|Other Names||Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.|
|Tissue Location||Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon.|
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Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Lucka L.,et al.FEBS Lett. 454:341-344(1999).
Seppala R.,et al.Am. J. Hum. Genet. 64:1563-1569(1999).
Wang S.S.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Huizing M.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Pramono Z.A.D.,et al.Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
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