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Synuclein γ Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | O76070 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13,(actual)17 KDa |
| Antigen Region | 98-127 aa |
| Gene ID | 6623 |
|---|---|
| Other Names | Gamma-synuclein, Breast cancer-specific gene 1 protein, Persyn, Synoretin, SR, SNCG, BCSG1, PERSYN, PRSN |
| Dilution | WB~~1:1000 IHC~~1:50-1:100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | SNCG |
|---|---|
| Synonyms | BCSG1, PERSYN, PRSN |
| Function | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle |
| Tissue Location | Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
References
Ji H.,et al.Cancer Res. 57:759-764(1997).
Ninkina N.N.,et al.Hum. Mol. Genet. 7:1417-1424(1998).
Lavedan C.,et al.Hum. Genet. 103:106-112(1998).
Han C.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Pronin A.N.,et al.J. Biol. Chem. 275:26515-26522(2000).
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