|Application ||WB, E|
|Calculated MW||60033 Da|
|Antigen Region||254-279 aa|
|Other Names||Transcription factor GATA-6, GATA-binding factor 6, GATA6|
|Target/Specificity||This GATA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-279 amino acids from human GATA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GATA6-Y271 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).|
|Tissue Location||Expressed in heart, gut and gut-derived tissues|
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Provided below are standard protocols that you may find useful for product applications.
GATA6 is thought to be important for regulating terminal differentiation and/or proliferation.
Capo-chichi, C.D., et al. Mol. Cell. Biol. 29(17):4766-4777(2009) Nakamura, Y., et al. Endocrinology 150(9):4145-4153(2009) Tan, N.Y., et al. Circ. Res. 105(5):422-430(2009)
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