|Calculated MW||37 34 KDa|
|Antigen Region||280-309 aa|
|Other Names||Nuclear transcription factor Y subunit alpha, CAAT box DNA-binding protein subunit A, Nuclear transcription factor Y subunit A, NF-YA, NFYA|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
Li X.-Y.,et al.Nucleic Acids Res. 20:1087-1091(1992).
Mungall A.J.,et al.Nature 425:805-811(2003).
Becker D.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1968-1972(1991).
Yamada K.,et al.Biochem. Biophys. Res. Commun. 261:614-621(1999).
Yamada K.,et al.FEBS Lett. 460:41-45(1999).
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