|Calculated MW||140，128 KDa|
|Antigen Region||1190-1214 aa|
|Other Names||Chromosome-associated kinesin KIF4A, Chromokinesin-A, KIF4A, KIF4|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.|
|Cellular Location||Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis|
|Tissue Location||Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow Lower levels are found in heart, testis, kidney, colon and lung|
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Provided below are standard protocols that you may find useful for product applications.
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
Villard L.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Oh S.J.,et al.Biochim. Biophys. Acta 1493:219-224(2000).
Rentsch A.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
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