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ABCD3 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ABCD3 Antibody AP50722
    Western blot analysis of lysate from SH-SY5Y cell line,using ABCD3 Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P28288
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 75,63,27 KDa
Antigen Region 30-90 aa
Additional Information
Gene ID 5825
Other Names ATP-binding cassette sub-family D member 3, 70 kDa peroxisomal membrane protein, PMP70, ABCD3, PMP70, PXMP1
Dilution WB~~ 1:1000
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ABCD3 (HGNC:67)
Function Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long- chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched- chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:25168382, PubMed:24333844, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl- CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:25944712, PubMed:24333844).
Cellular Location Peroxisome membrane; Multi-pass membrane protein
Research Areas
Citations (0)
citation

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Background

Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.

References

Gaertner J.,et al.Nat. Genet. 1:16-23(1992).
Kamijo K.,et al.Biochim. Biophys. Acta 1129:323-327(1992).
Gaertner J.,et al.Genomics 48:203-208(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 350.00
Cat# AP50722
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Availability: 2 weeks
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