|Reactivity||Human, Mouse, Rat|
|Calculated MW||53,51,41,24,30,31 KDa|
|Antigen Region||310-370 aa|
|Other Names||Calcium-binding tyrosine phosphorylation-regulated protein, Calcium-binding protein 86, Cancer/testis antigen 88, CT88, Fibrousheathin II, Fibrousheathin-2, FSP-2, Testis-specific calcium-binding protein CBP86, CABYR, CBP86, FSP2|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella Isoform 3: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic|
|Tissue Location||Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.|
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May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
Naaby-Hansen S.,et al.Dev. Biol. 242:236-254(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Hsu H.-C.,et al.Biochem. Biophys. Res. Commun. 329:1108-1117(2005).
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