|Reactivity||Human, Mouse, Rat|
|Calculated MW||57 KDa|
|Antigen Region||143-203 aa|
|Other Names||Excitatory amino acid transporter 3, Excitatory amino-acid carrier 1, Neuronal and epithelial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 member 1, SLC1A1, EAAC1, EAAT3|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers)|
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Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
Shashidharan P.,et al.Brain Res. 662:245-250(1994).
Kanai Y.,et al.J. Biol. Chem. 269:20599-20606(1994).
Arriza J.L.,et al.J. Neurosci. 14:5559-5569(1994).
Veenstra-VanderWeele J.,et al.Mol. Psychiatry 6:160-167(2001).
Yasuda-Kamatani Y.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
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