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LZTR1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LZTR1 Antibody AP50731
    Western blot analysis of lysate from Hela cell line,using LZTR1 Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8N653
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 95 KDa
Antigen Region 332-392 aa
Additional Information
Gene ID 8216
Other Names Leucine-zipper-like transcriptional regulator 1, LZTR-1, LZTR1, TCFL2
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, 50% Glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name LZTR1 {ECO:0000303|PubMed:7633402, ECO:0000312|HGNC:HGNC:6742}
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304).
Cellular Location Endomembrane system. Recycling endosome. Golgi apparatus
Research Areas
Citations (0)
citation

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Background

Probable transcriptional regulator that may play a crucial role in embryogenesis.

References

Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kurahashi H.,et al.Hum. Mol. Genet. 4:541-549(1995).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).

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$ 350.00
Cat# AP50731
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Quantity:
Availability: 2 weeks
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