LZTR1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8N653 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 95 KDa |
Antigen Region | 332-392 aa |
Gene ID | 8216 |
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Other Names | Leucine-zipper-like transcriptional regulator 1, LZTR-1, LZTR1, TCFL2 |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, 50% Glycerol |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | LZTR1 {ECO:0000303|PubMed:7633402, ECO:0000312|HGNC:HGNC:6742} |
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Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). |
Cellular Location | Endomembrane system. Recycling endosome. Golgi apparatus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable transcriptional regulator that may play a crucial role in embryogenesis.
References
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kurahashi H.,et al.Hum. Mol. Genet. 4:541-549(1995).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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