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OPTC Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UBM4 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37 KDa |
| Antigen Region | 269-329 aa |
| Gene ID | 26254 |
|---|---|
| Other Names | Opticin, Oculoglycan, OPTC, OPT |
| Dilution | WB~~ 1:1000 |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | OPTC |
|---|---|
| Synonyms | OPT |
| Function | Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed in cartilage and synovial membranes (at protein level) (PubMed:18164633, PubMed:23845380). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level) (PubMed:12019215, PubMed:25136834). Expressed in the retinal pigment epithelium (at protein level) (PubMed:25136834). Expressed in synovial fibroblasts and subchondral bone osteoblasts (PubMed:18164633) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Binds collagen fibrils (By similarity).
References
Reardon A.J.,et al.J. Biol. Chem. 275:2123-2129(2000).
Hobby P.,et al.Mol. Vis. 6:72-78(2000).
Friedman J.S.,et al.Invest. Ophthalmol. Vis. Sci. 41:2059-2066(2000).
Friedman J.S.,et al.Hum. Mol. Genet. 11:1333-1342(2002).
Gregory S.G.,et al.Nature 441:315-321(2006).
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