|Reactivity||Human, Mouse, Rat|
|Calculated MW||44 KDa|
|Antigen Region||17-45 aa|
|Other Names||General transcription factor IIH subunit 2, Basic transcription factor 2 44 kDa subunit, BTF2 p44, General transcription factor IIH polypeptide 2, TFIIH basal transcription factor complex p44 subunit, GTF2H2, BTF2P44|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter.|
|Tissue Location||Widely expressed, with higher expression in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter.
Humbert S.,et al.EMBO J. 13:2393-2398(1994).
Zhang Q.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
van der Steege G.,et al.Eur. J. Hum. Genet. 3:87-95(1995).
Chen Q.,et al.Genomics 48:121-127(1998).
Kershnar E.,et al.J. Biol. Chem. 273:34444-34453(1998).
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