|Reactivity||Human, Mouse, Rat|
|Calculated MW||43 KDa|
|Antigen Region||321-349 aa|
|Other Names||POU domain, class 4, transcription factor 1, Brain-specific homeobox/POU domain protein 3A, Brain-3A, Brn-3A, Homeobox/POU domain protein RDC-1, Oct-T1, POU4F1, BRN3A, RDC1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Multifunctional transcription factor with different regions mediating its different effects. Acts by binding through its C-terminal domain to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of their target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that some of these genes require its N-terminal in order to be activated, maybe through a neuronal- specific cofactor. Ativates BCL2 expression and protect neuronal cells from apoptosis, through the N-terminal domain. Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.|
|Tissue Location||Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye|
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Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.
Bhargava A.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10260-10264(1993).
Xiang M.,et al.J. Neurosci. 15:4762-4785(1995).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Collum R.G.,et al.Nucleic Acids Res. 20:4919-4925(1992).
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