|Reactivity||Human, Mouse, Rat|
|Calculated MW||118 KDa|
|Antigen Region||215-241 aa|
|Other Names||Membrane-bound transcription factor site-1 protease, Endopeptidase S1P, Subtilisin/kexin-isozyme 1, SKI-1, MBTPS1, KIAA0091, S1P, SKI1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Synonyms||KIAA0091, S1P, SKI1|
|Function||Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=May sort to other organelles, including lysosomal and/or endosomal compartments|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu.
Nakajima T.,et al.J. Hum. Genet. 45:212-217(2000).
Nagase T.,et al.DNA Res. 2:37-43(1995).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Toure B.B.,et al.J. Biol. Chem. 275:2349-2358(2000).
Seidah N.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:1321-1326(1999).
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