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SLC4A8/10 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q2Y0W8 |
| Other Accession | Q6U841 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 123,121,117,112,77,84 KDa |
| Antigen Region | 401-426 aa |
| Gene ID | 9498 |
|---|---|
| Other Names | Electroneutral sodium bicarbonate exchanger 1, Electroneutral Na(+)-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3, S4A8 |
| Dilution | WB~~ 1:1000 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | SLC4A8 {ECO:0000312|EMBL:AAY79176.1, ECO:0000312|HGNC:HGNC:11034} |
|---|---|
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein [Isoform 3]: Cell membrane; Multi-pass membrane protein [Isoform 5]: Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. [Isoform 4]: Expressed in the brain, heart and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
References
Grichtchenko I.I.,et al.J. Biol. Chem. 276:8358-8363(2001).
Bouyer P.,et al.Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 5:277-286(1998).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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