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TOR1AIP1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q5JTV8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 66,43 KDa |
| Antigen Region | 450-478 aa |
| Gene ID | 26092 |
|---|---|
| Other Names | Torsin-1A-interacting protein 1, Lamin-associated protein 1B, LAP1B, TOR1AIP1, LAP1 |
| Dilution | WB~~ 1:1000 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | TOR1AIP1 |
|---|---|
| Synonyms | LAP1 |
| Function | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. |
| Cellular Location | Nucleus inner membrane; Single-pass membrane protein |
| Tissue Location | Expressed in muscle, liver and kidney. [Isoform 4]: Expressed at higher levels than isoform 1 in lung, kidney and spleen (at protein level). Expressed at lower levels than isoform 1 in liver, brain and heart (at protein level). Similar levels of isoforms 1 and 4 are observed in ovary, testis and pancreas (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina (By similarity).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kondo Y.,et al.Biochem. Biophys. Res. Commun. 294:770-778(2002).
Goodchild R.E.,et al.J. Cell Biol. 168:855-862(2005).
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