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HAS2 antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q92819 |
| Reactivity | Human, Mouse, Rat, Pig, Chicken, Sheep, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=64;M=64;R=64 KDa |
| Antigen Region | 401-500/552 human aa |
| Gene ID | 3037 |
|---|---|
| Other Names | Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | HAS2 (HGNC:4819) |
|---|---|
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (PubMed:20507985, PubMed:32993960, PubMed:23303191, PubMed:21228273) (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:8798477, PubMed:21228273, PubMed:20507985). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi- pass membrane protein. Vesicle. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles (PubMed:30394292). Post-translational modifications control HAS2 trafficking (PubMed:30394292). |
| Tissue Location | Expressed in fibroblasts. |
Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).
References
Watanabe K.,et al.J. Biol. Chem. 271:22945-22948(1996).
Morerio C.,et al.Cancer Genet. Cytogenet. 156:183-184(2005).
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