|Reactivity||Human, Mouse, Rat|
|Calculated MW||25,13,10 KDa|
|Antigen Region||76-103 aa|
|Other Names||Sodium channel subunit beta-4, SCN4B|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.|
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Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity).
Yu F.H.,et al.J. Neurosci. 23:7577-7585(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).
Medeiros-Domingo A.,et al.Circulation 116:134-142(2007).
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