|Application ||WB, IHC-P, E|
|Calculated MW||49754 Da|
|Antigen Region||281-309 aa|
|Other Names||UBX domain-containing protein 6, UBX domain-containing protein 1, UBXN6, UBXD1, UBXDC2|
|Target/Specificity||This UBXN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the C-terminal region of human UBXN6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBXN6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the centrosome both in interphase and during mitosis|
|Tissue Location||Enhanced expression in testis.|
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Provided below are standard protocols that you may find useful for product applications.
UBXN6 acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. UBXN6 is MDM2 stabilization leads to MDM2-dependent TP53 degradation.
Nagahama, M., et al. Biochem. Biophys. Res. Commun. 382(2):303-308(2009)
Kern, M., et al. Biochem. Biophys. Res. Commun. 380(2):303-307(2009)
Madsen, L., et al. Int. J. Biochem. Cell Biol. 40(12):2927-2942(2008)
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