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AQP1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P29972 |
| Reactivity | Human, Mouse, Rat, Sheep, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28; [uniprot]28,20,23,17; KDa |
| Antigen Region | 181-269/269 aa |
| Gene ID | 358 |
|---|---|
| Other Names | Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28 |
| Dilution | WB~~1:100~1:500 IHC-P~~1:100~1:500 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | AQP1 (HGNC:633) |
|---|---|
| Synonyms | CHIP28 |
| Function | Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:1373524). Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
References
Preston G.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:11110-11114(1991).
Moon C.,et al.J. Biol. Chem. 268:15772-15778(1993).
Ruiz A.C.,et al.Biochim. Biophys. Acta 1282:174-178(1996).
Li X.,et al.Biochem. Mol. Biol. Int. 32:371-377(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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