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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-B7-DC antibody    

Anti-B7-DC antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - Anti-B7-DC antibody
    Formalin-fixed and paraffin embedded human cervical cancer labeled with Anti-B7-DC/CD273/PDL2, Unconjugated (AP50869) followed by conjugation to the secondary antibody
  • WB - Anti-B7-DC antibody
    Western blot analysis of lysate from Hela cell line,using Anti-B7-DC antibody (AP50869). AP50869 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysate at 35ug.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BQ51
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa,21KD
Antigen Region 41-150/273 aa
Additional Information
Gene ID 80380
Other Names Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273, PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Dilution IHC-P~~1:100~1:500
WB~~ 1:1000
Format0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃.
Protein Information
Synonyms B7DC, CD273, PDCD1L2, PDL2
Function Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Cellular Location Isoform 3: Secreted. Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.
Research Areas
Citations (0)

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B7DC is a 33kDa member of the immunoglobulin receptor superfamily expressed on DC, liver and a small subset of macrophages as well as a few transformed cell lines. B7DC has been reported to be stimulatory on dendritic cells when cross linked and to inhibit T cell activation upon engaging the PD1 receptor. B7DC has also been reported to bind to an alternative receptor and to mediate T cell activation through non PD1 mediated interactions


Tseng S.-Y.,et al.J. Exp. Med. 193:839-846(2001).
Latchman Y.,et al.Nat. Immunol. 2:261-268(2001).
He X.-H.,et al.Acta Biochim. Biophys. Sin. 36:284-289(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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$ 295.00
Cat# AP50869
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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