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AQP4 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P55087 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35,32 KDa |
| Antigen Region | 231-280 aa |
| Gene ID | 361 |
|---|---|
| Other Names | Aquaporin-4, AQP-4, Mercurial-insensitive water channel, MIWC, WCH4, AQP4 |
| Dilution | WB~~ 1:500 |
| Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 52% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | AQP4 |
|---|---|
| Function | Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:P55088}; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection {ECO:0000250|UniProtKB:P47863}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries {ECO:0000250|UniProtKB:P47863} |
| Tissue Location | Detected in skeletal muscle (PubMed:29055082). Detected in stomach, along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary (PubMed:7559426, PubMed:8601457). |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
References
Yang B.,et al.J. Biol. Chem. 270:22907-22913(1995).
Misaka T.,et al.FEBS Lett. 381:208-212(1996).
Lu M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:10908-10912(1996).
Nusbaum C.,et al.Nature 437:551-555(2005).
Lanciotti A.,et al.Hum. Mol. Genet. 21:2166-2180(2012).
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$ 360.00
Cat# AP50937
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